1-methyl-3-phenyl-7-benzylaminopyrazolo[3,4-d]pyridazine

Compound 10b is a synthetic small molecule featuring a novel pyrazolo[3,4-d]pyridazine scaffold that acts as a potent dual antagonist for the adenosine A1 and A3 receptors. It demonstrates high binding affinity for the human A1 receptor (21 nM) and the human A3 receptor (55 nM), with residence times of approximately 60 and 73 minutes, respectively. It shows significantly lower affinity for the adenosine A2B receptor (1.7 μM). Identified through academic research published in ACS Medicinal Chemistry Letters, this compound serves as a lead scaffold for the development of adenosine receptor ligands. Preliminary toxicological evaluations in cell lines have indicated no significant toxicity, although no specific therapeutic indications or commercial developers have been identified for this research-stage compound.

Other names

N-benzyl-1-methyl-3-phenyl-1H-pyrazolo[3,4-d]pyridazin-7-amine